Biographie Mélèze HOCINI

Dr. Mélèze HOCINI, MD, is an Associate Professor at Bordeaux University Hospital, Department of Cardiac arrhythmias center in Bordeaux, France. She has more than 20 years of experience in catheter ablation procedures, including atrial fibrillation ablation and ablation of ventricular fibrillation (VF). Her research interests focus on the mechanisms of atrial rhythm disorders and their treatment, as well as mapping and treatment of ventricular fibrillation and evaluation of patients at risk of sudden cardiac death.

After graduating in medicine in 1996, she went on to specialize in cardiac electrophysiology and started off with research on the electrophysiological properties of the pulmonary veins in large animal models and in patients. She has been strongly implicated in the development and evaluation of several innovative therapeutic strategies in atrial fibrillation. Some discoveries led to the development of a curative treatment recommended by international guidelines currently benefiting several hundreds of thousands of patients every year worldwide. She has also a keen interest in lethal ventricular arrhythmias, particularly ventricular fibrillation in different patient populations (IVF, J wave syndromes, ischemic VF, and VF in the setting of hypertrophic cardiomyopathy). She is currently leading the first large-scale study on the characterization of human VF dynamics in various patient populations to better understand VF mechanisms and to propose solutions to detect and prevent patients at risk of SCD.

Dr. Hocini has been an invited lecturer to numerous international conferences and has published over 400 peer-reviewed research articles in high-profile journals such as New England journal of Medicine, Lancet, JAMA, Circulation, JACC, PACE, and Nature reviews. She has authored multiple chapters in medical textbooks related to her specialty interest and published numerous abstracts.

Dr. Hocini has mentored many international students, PhDs and research fellows who first-authored peer-reviewed original research papers in some of the top journals in the field of cardiac electrical disorders

Finally, in 2010, she was part of the team involved in the creation of the research institute Liryc (Electrophysiology and Heart Modeling Institute) of which she has been the Deputy Director since 2013, bringing her new administrative and scientific responsibilities. More recently, she has taken up the role of Director of the Liryc fundraising campaign in order to improve innovation, inform people and raise their awareness about cardiac electrical disease.

Education

Cardiology

1998 : Resident: University of Bordeaux II, Fr
1998 : Inter-University degree (DIU) in Cardiac Pacing University of Bordeaux II, Fr
1998 : University degree (DU) in Echocardiography and Cardiac Echo-Doppler University of Bordeaux II, Fr
1996 : Specialization in Cardiology (DES) University of Bordeaux II, Fr
1996 : Medical Doctor Degree University of Bordeaux II, Fr

Biological sciences

1998 : Research in fundamental electrophysiology University of Amsterdam, the Netherlands (1996-1998)
1995 : Postgraduate Research Degree (DEA) in Electrophysiology and Circulatory System University of Lariboisière, Paris, Fr
1994 : Master of Biological and Medical Sciences University of Bordeaux II, Fr

Current positions

From 2007 Associate Professor (MCU) – College of Health Sciences, University of Bordeaux
Hospital Practitioner (PH) – Bordeaux University Hospital, Cardiologic Hospital, Haut-Lévêque, Pessac, Fr

Previous positions

2002 – 2007 : Hospital Practitioner Bordeaux University Hospital, Cardiologic Hospital, Haut-Lévêque, Pessac, Fr
1998 – 2002 : Bordeaux Hospitals Assistant Bordeaux University Hospital, Cardiologic Hospital, Haut-Lévêque, Pessac, Fr
< 1998 : Bordeaux Hospitals Intern CHU Bordeaux, CH Bayonne and CH Libourne

Supervision of graduate students

2019 : CHURET M ; 2018: DELFANNE C MD:. 2016: DUCHATEAU J: MD. 2016: FRUQUIIERE B: MD. 2016: BARRITAULT F: MD. 2016: MARTINEZ M: PhD. 2013: LAINE M: MD. 2013: YAHFOUFI H: MD. 2012: BARREAU L: MD. 2012: DUBOIS R: HDR. 2012: FARARIK M: MD.

Supervision of postdoctoral fellows

PASCAREL-AUCLERC Caroline, Tempo project
MEO Mariana: Treatment of the endocavitary signal and the extraction of characteristics in order to guide the AF ablation
MARTINEZ Marine, Symphony project
POURTEAU Line: Platelets
SELLAL Jean Marc : VT mechanisms and imaging

Teaching activities

Lectures for undergraduate and graduate students at the Faculty of Medicine, University of Bordeaux: Teaching Medical Students (CDR 2 AND DCEM2) in Cardiology
Teaching of students in the second cycle of medical studies
Teaching of clinic managers
Teaching for the inter-university diploma in electrophysiology
Teaching of paramedical staff
Continuing education for liberal doctors of Aquitaine region
Training of physicians in the techniques used in the service
Teaching and training for foreign physicians

Organisation of scientific meetings

ISCAT (‘Symposium International sur les Techniques Ablatives’), Paris, Fr
ALLIANCE (Boston Scientific): ‘State of the art in electrical management diseases’
CARDIOSTIM – World Scientific Congress in cardiac electrophysiology and cardiac techniques
BOSTON AF Symposium
CHFS (Chinese AF symposium)
ATRIAL SIGNALS meeting (Physicians meet engineers)
AF SUMMIT – Heart Rhythm Society (HRS)

Institutional responsabilities

From 2018:- Director of the fundraising campaign for the Liryc Institute (IHU-Liryc), Pessac
From 2013 – Deputy Director of the Liryc Institute (IHU-Liryc), Pessac
From 2011 – Member of the National Council of Universities
Member of Medtronic Advisory Board

Reviewer for international journals

Circulation. Nature reviews. European heart. Heart Rhythm. Circulation Electrophysiology & Arrhythmia. Journal of the American College of Cardiology. American Journal of physiology. Journal of Cardiovascular of Electrocardiology. Journal of Interventional Cardiac Electrophysiology.

Reviewer for international grants

Reviewer for the National society of Switzerland
Reviewer for the National society of the Netherlands

Memberships of scientific societies

Associate member of ‘Société Française de Cardiologie’
Member of the European Heart Rhythm association (EHRA), Certification board EHRA and the SIC (Scientific initiative committee) EHRA.
Member of the Editorial board of Chinese Medical Journal
Member of the scientific council of the Fondation Coeur et Recherche

Major international collaborations

Prof. Igor Efimov, Department of Biomedical Engineering, The George Washington University, USA
Prof. Natalia Trayanova, Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, USA
Prof. Hugh Calkins, greater Baltimore Medical Center, Johns Hopkins Bayview Medical Center, USA
Dr Hiroshi Ashikaga, Johns Hopkins Hospital, Baltimore, USA
Dr Ruben Coronel, Exp. Cardiology, Amsterdam Medical Center, The Netherlands
Prof. Janse Michael Exp. Cardiology, Amsterdam Medical Center, The Netherlands
Prof. Jalife José internal medicine and molecular and integrative physiology, University of Michigan Medical School, USA
Prof. Yen Ho Cardiac Morphology, Royal Brompton Hospital, Imperial College London, GB
Prof. Stanley Nattel University of Montreal and Montreal Heart Institute, Canada

Track-record

Key bibliometric numbers

H index: 76 (Web of sciences, career period 1996-2019)
Publications: More than 400 publications for career period, 24189 citations based on 328 papers

1. Up to ten representative publications, from the last ten years, as main author in major international peer-reviewed multi-disciplinary scientific journals

Komatsu Y, Hocini M, Nogami A, Maury P, Peichl P, Iwasaki YK, Masuda K, Denis A, Voglimacci-Stephanopoli Q, Wichterle D, Kawamura M, Fukamizu S, Yokoyama Y, Mukai Y, Harada T, Yoshida K, Yasuoka R, Igawa M, Ohira K, Shimizu W, Aonuma K, Kautzner J, Haïssaguerre M, Ieda M. Catheter Ablation of Refractory Ventricular Fibrillation Storm After Myocardial Infarction: A Multicenter Study. Circulation. 2019; 139: 2315–2325
*Komatsu and Hocini contributed equally to the manuscript

Lim HS, Hocini M, Dubois R, Denis A, Derval N, Zellerhoff S, Yamashita S, Berte B, Mahida S, Komatsu Y, Daly M, Jesel L, Pomier C, Meillet V, Amraoui S, Shah AJ, Cochet H, Sacher F, Jaïs P, Haïssaguerre M. Complexity and Distribution of Drivers in Relation to Duration of Persistent Atrial Fibrillation. JACC, Volume 69, Issue 10, March 2017.

Zhang, J.; Hocini, M.; Strom, M.; Cuculich, P.S.; Cooper, D.H.; Sacher, F.; Haissaguerre, M.; Rudy, Y. The Electrophysiological Substrate of Human Early Repolarization Syndrome: Noninvasive Mapping with ECGI. JACC Clinical Electrophysiology 3(8) 2017.

Hocini, M.; Condie, C.; Stewart, M. T.; Kirchhof, N.; Foell, J. D., Predictability of lesion durability for AF ablation using phased radiofrequency: Power, temperature, and duration impact creation of transmural lesions. Heart Rhythm 2016, 13 (7), 1521-6.

Hocini, M.; Shah, A. J.; Neumann, T.; Kuniss, M.; Erkapic, D.; Chaumeil, A.; Copley, S. J.; Lim, P. B.; Kanagaratnam, P.; Denis, A.; Derval, N.; Dubois, R.; Cochet, H.; Jais, P.; Haissaguerre, M., Focal Arrhythmia Ablation Determined by High-Resolution Noninvasive Maps: Multicenter Feasibility Study. J Cardiovasc Electrophysiol 2015, 26 (7), 754-60.

Hocini, M.; Pison, L.; Proclemer, A.; Larsen, T. B.; Madrid, A.; Blomstrom-Lundqvist, C.; Scientific Initiative Committee, E. H. R. A., Diagnosis and management of patients with inherited arrhythmia syndromes in Europe: results of the European Heart Rhythm Association Survey. Europace 2014, 16 (4), 600-3.

Hocini, M.; Shah, A. J.; Denis, A.; Cochet, H.; Haissaguerre, M., Noninvasive 3D mapping system guided ablation of anteroseptal pathway below the aortic cusp. Heart Rhythm 2013, 10 (1), 139-41.

Hocini, M.; Shah, A. J.; Cochet, H.; Maury, P.; Denis, A.; Haissaguerre, M., Noninvasive electrocardiomapping facilitates previously failed ablation of right appendage diverticulum associated life-threatening accessory pathway. J Cardiovasc Electrophysiol 2013, 24 (5), 583-5.

Hocini, M.; Shah, A. J.; Nault, I.; Rivard, L.; Linton, N.; Narayan, S.; Myiazaki, S.; Jadidi, A. S.; Knecht, S.; Scherr, D.; Wilton, S. B.; Roten, L.; Pascale, P.; Pedersen, M.; Derval, N.; Sacher, F.; Jais, P.; Clementy, J.; Haissaguerre, M., Mitral isthmus ablation with and without temporary spot occlusion of the coronary sinus: a randomized clinical comparison of acute outcomes. J Cardiovasc Electrophysiol 2012, 23 (5), 489-96.

Hocini, M.; Shah, A. J.; Nault, I.; Sanders, P.; Wright, M.; Narayan, S. M.; Takahashi, Y.; Jais, P.; Matsuo, S.; Knecht, S.; Sacher, F.; Lim, K. T.; Clementy, J.; Haissaguerre, M., Localized reentry within the left atrial appendage: arrhythmogenic role in patients undergoing ablation of persistent atrial fibrillation. Heart Rhythm 2011, 8 (12), 1853-61.

Hocini, M.; Nault, I.; Wright, M.; Veenhuyzen, G.; Narayan, S. M.; Jais, P.; Lim, K. T.; Knecht, S.; Matsuo, S.; Forclaz, A.; Miyazaki, S.; Jadidi, A.; O’Neill, M. D.; Sacher, F.; Clementy, J.; Haissaguerre, M., Disparate evolution of right and left atrial rate during ablation of long-lasting persistent atrial fibrillation. J Am Coll Cardiol 2010, 55 (10), 1007-16.

2. Granted patents;

Mono-Phasic Action Potential Electrogram Recording Catheter – EP2932999 (2015)

Co-Inventor: HOCINI Mélèze
Applicant: Medtronic ablation frontiers LLC

3. Invited presentations to internationally established conferences

302 written and oral papers submitted to refereed meetings at international congresses
>200 invited presentations at national and international congresses (HRS, Venice Arrhythmias, ISCAT, Cardiostim, Europace, APHRS, AHA, ESC …)

4. Research grants

PIC: MSCA-ITN-2017 ‘Personalised in silico Cardiology’ (48 months, 262 800€) – Co-Investigator
RHYTHM: Imaging of heterogeneity of repolarization for personalized cardiac arrhythmia therapy (Fondation Leducq network 2016) (5 years, 1 435 000€) – Co-Investigator
PURKINJE CRA: Characterization of the Purkinje network from the cell to the organ, based on the imaging of the cellular tissue and the clinical data (Région Nouvelle Aquitaine – 2016) (2 years, 135 000€) – Project coordinator
Mapping of sources and substrate of fibrillatory cardiac arrhythmias in the left atrium (Fondation Cœur et Recherche, AAP dotations 2011) (22 months, 80 000€) – Project coordinator
TEMPO: Mechanisms to trigger ectopic activity and pulmonary vein substrate (ANR – 2012)(48 months, 379 000€) – Principal investigator

5. Prizes/ Awards/ Academy memberships

‘Federation Française de Cardiologie’ Fellowship (1997)
Sanofi-Synthelabo award (2003)
Philippe Coumel Prize (2004)
Chinese Symposium Award (China atrial fibrillation symposium) (2008)
‘Fondation Cœur & Recherche’ Prize (2011)

‘L’académie de Médecine et des beaux-arts’ Prize (2013)